Italian Chicken, Mushrooms & Zucchini Skillet (Anti-Inflammatory Recipe)
📖 Description
This Italian Chicken, Mushrooms & Zucchini Skillet is a nutrient-dense, anti-inflammatory dinner packed with lean protein, antioxidant-rich vegetables, and heart-healthy olive oil. Tender, golden-seared chicken breasts are topped with savory sautéed mushrooms and zucchini, simmered in a light garlic-herb sauce.
Perfect for a healthy Mediterranean diet meal plan, this one-pan recipe is low-carb, gluten-free, keto-friendly, and ideal for clean eating or weight management.
🛒 Ingredients (Serves 4)
Protein
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4 boneless, skinless chicken breasts
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1 tsp sea salt
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½ tsp black pepper
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1 tsp Italian seasoning
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½ tsp paprika
Vegetables
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2 medium zucchini, sliced into rounds
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8 oz cremini or button mushrooms, sliced
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3 cloves garlic, minced
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2 tbsp fresh parsley, chopped
Sauce
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3 tbsp extra virgin olive oil (anti-inflammatory healthy fat)
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½ cup organic chicken broth (low sodium)
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1 tbsp fresh lemon juice
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¼ tsp red pepper flakes (optional)
👩🍳 Instructions
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Season Chicken
Pat chicken dry. Season both sides with salt, pepper, paprika, and Italian seasoning. -
Sear Chicken
Heat 2 tbsp olive oil in a large skillet over medium heat.
Sear chicken for 5–6 minutes per side until golden brown and internal temp reaches 165°F (74°C).
Remove from skillet and set aside. -
Sauté Vegetables
Add remaining olive oil.
Add zucchini and mushrooms. Cook 4–5 minutes until tender.
Stir in garlic and cook 30 seconds until fragrant. -
Create Sauce
Pour in chicken broth and lemon juice.
Simmer 2–3 minutes, scraping browned bits for flavor. -
Combine & Finish
Return chicken to skillet. Spoon mushrooms and zucchini over top.
Simmer 3–4 minutes until heated through.
Garnish with fresh parsley and red pepper flakes.
🌿 Why This Is Anti-Inflammatory
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Extra virgin olive oil – rich in oleocanthal (natural anti-inflammatory compound)
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Garlic – immune-boosting and anti-inflammatory
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Zucchini & mushrooms – high in antioxidants and fiber
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Lean chicken breast – clean protein source
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Lemon juice – supports digestion and detoxification
This makes it an excellent anti-inflammatory dinner recipe for chronic inflammation, arthritis support, and gut health.
🍽 Serving Suggestions
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Serve over cauliflower rice for a low-carb keto meal
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Pair with quinoa for a balanced Mediterranean bowl
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Add a side of mixed greens with balsamic vinaigrette
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Top with shaved Parmesan for extra richness
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Serve alongside roasted sweet potatoes for a comforting healthy dinner
🔄 Variations
Creamy Italian Version
Add ¼ cup coconut milk or Greek yogurt for a creamy anti-inflammatory sauce.
Dairy-Free & Whole30
Keep as written; ensure broth is Whole30 compliant.
Low-Calorie Meal Prep
Slice chicken before storing in airtight containers for easy weekly meal prep.
Add More Anti-Inflammatory Boost
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Add turmeric (¼ tsp)
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Add fresh thyme or rosemary
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Sprinkle chia or hemp seeds before serving
❓ Related Questions
Is zucchini anti-inflammatory?
Yes, zucchini contains antioxidants like vitamin C and carotenoids that help reduce inflammation.
Can I use chicken thighs instead of breasts?
Absolutely. Boneless skinless thighs work well and provide extra juiciness.
How long does it last in the fridge?
Up to 4 days stored in airtight containers.
Is this recipe keto-friendly?
Yes. It’s naturally low in carbohydrates and high in protein and healthy fats.
Can I freeze this dish?
Yes, though zucchini texture may soften slightly upon reheating.
🥗 Nutrition Information (Per Serving – Approximate)
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Calories: 320
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Protein: 38g
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Fat: 16g
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Carbohydrates: 8g
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Fiber: 2g
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Sugar: 4g
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Sodium: 340mg
This is considered a high-protein low-carb anti-inflammatory meal suitable for weight loss and blood sugar balance.
💡 Expert Tips for Best Flavor
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Don’t overcrowd the pan — sear chicken in batches if needed.
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Let chicken rest 5 minutes before slicing to retain juices.
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Use fresh herbs for maximum antioxidant benefit.
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Deglaze properly to capture rich skillet flavor.
🏆 Final Thoughts
This Italian Chicken, Mushrooms & Zucchini Skillet is the ultimate healthy one-pan Mediterranean dinner — simple, flavorful, and packed with inflammation-fighting ingredients. Whether you’re following a keto diet, anti-inflammatory meal plan, or just want a wholesome family dinner, this recipe delivers restaurant-quality results with minimal effort.

