Roasted Butternut Squash Orzo (Anti-Inflammatory Recipe)
🌿 Description
This Roasted Butternut Squash Orzo with Spinach is a vibrant, plant-based comfort dish packed with anti-inflammatory ingredients. Sweet caramelized butternut squash pairs beautifully with tender orzo, wilted spinach, garlic, olive oil, and optional balsamic glaze.
Rich in antioxidants, fiber, vitamin A, and heart-healthy fats, this easy healthy dinner recipe supports immune health, gut health, and overall wellness. It’s perfect for meal prep, clean eating, and Mediterranean diet lovers.
🛒 Ingredients (Serves 4)
For the Roasted Squash:
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3 cups butternut squash, peeled & cubed
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2 tbsp extra virgin olive oil
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½ tsp turmeric (anti-inflammatory boost)
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½ tsp smoked paprika
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¼ tsp black pepper
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Sea salt to taste
For the Orzo:
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1 cup whole wheat or regular orzo pasta
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2 cloves garlic, minced
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2 cups fresh spinach
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1 tbsp olive oil
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1 tbsp balsamic glaze (optional)
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¼ cup grated Parmesan (optional or use nutritional yeast for vegan)
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1 tbsp chia seeds or black sesame seeds (optional superfood topping)
👩🍳 Instructions
1️⃣ Roast the Squash
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Preheat oven to 400°F (200°C).
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Toss squash with olive oil, turmeric, paprika, salt, and pepper.
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Spread on baking sheet and roast 25–30 minutes until golden and tender.
2️⃣ Cook the Orzo
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Boil salted water and cook orzo according to package instructions (8–10 minutes).
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Drain and set aside.
3️⃣ Sauté & Combine
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Heat olive oil in a pan over medium heat.
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Add garlic and sauté 30 seconds.
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Stir in spinach until wilted.
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Add cooked orzo and roasted squash.
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Drizzle balsamic glaze and toss gently.
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Top with Parmesan and seeds if using.
Serve warm.
🍽 Serving Suggestions
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Pair with grilled salmon for an omega-3 anti-inflammatory boost
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Add grilled chicken for high-protein meal prep
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Serve alongside a fresh Mediterranean salad
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Enjoy as a vegetarian holiday side dish
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Pack for healthy office lunch
🔄 Variations
🌱 Vegan Version
Skip Parmesan and use nutritional yeast.
🥑 Low-Carb Option
Replace orzo with cauliflower rice.
🌶 Spicy Version
Add red pepper flakes or harissa.
🥜 Protein Boost
Add chickpeas or white beans.
🧀 Creamy Upgrade
Stir in a spoonful of Greek yogurt or goat cheese.
💪 Anti-Inflammatory Benefits
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Butternut squash – rich in beta-carotene (powerful antioxidant)
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Spinach – high in vitamin K and polyphenols
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Olive oil – heart-healthy monounsaturated fats
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Turmeric – contains curcumin, known for reducing inflammation
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Garlic – supports immune health
This recipe fits well into:
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Mediterranean diet meal plan
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Anti-inflammatory diet
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Clean eating lifestyle
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Plant-based nutrition plan
📊 Estimated Nutrition (Per Serving)
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Calories: ~320–380
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Protein: 9–14g
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Fiber: 5–7g
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Carbohydrates: 45g
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Healthy Fats: 12g
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Vitamin A: 200%+ Daily Value
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Iron: 10–15% DV
(Values vary depending on toppings and additions.)
❓ Related Questions
Is butternut squash good for inflammation?
Yes. It contains beta-carotene and vitamin C, which help reduce oxidative stress.
Can I make this gluten-free?
Yes, use gluten-free orzo or quinoa.
How long does it last in the fridge?
Up to 4 days in an airtight container.
Can I freeze it?
Yes, but texture may soften slightly after thawing.
Is this recipe good for weight loss?
Yes, it’s fiber-rich and nutrient-dense, helping promote fullness.
✨ Final Thoughts
This Roasted Butternut Squash Anti-Inflammatory Orzo Recipe is the perfect balance of comfort and wellness. It’s budget-friendly, meal-prep friendly, and packed with immune-boosting nutrients. Whether you’re following a Mediterranean diet, plant-based meal plan, or simply looking for healthy dinner ideas, this dish delivers both flavor and functional nutrition.

